These papers relate all to the developed technology and many of the authors are also co-owners of DelSiTech Ltd or of its mother company Bioxid Ltd.


Ahola M, Kortesuo P, Kangasniemi I, Kiesvaara J, Yli-Urpo A. In vitro release behaviour of toremifene citrate from sol-gel processed sintered solica xerogels. Drug Dev. & Ind. Pharm. 25 (1999) (8) 955 – 959.

Ahola M, Kortesuo P, Kangasniemi I, Kiesvaara J, Yli-Urpo A. Silica xerogel carrier material for controlled release of toremifen citrate. Int. J. Pharm. 195 (2000) 219 – 227.

Ahola M, Säilynoja ES, Raitavuo MH, Vaahtio MH, Salonen JI, Yli-Urpo AUO. In vitro release of heparin from silica xerogels. Biomat. (2001) 1-8.

Ahvenlammi J, Nousiainen P, Jokinen M, Peltola T and Veittola S, "Preparation of Sol-Gel Spun Glass Fibres for Biomaterials", Proceedings of FIBERMED 2000, June 12-14, 2000, Tampere, Finland, TTKK-Paino, ISBN 952-15-0423-4, pp. 175-185.

Areva S, Ääritalo V, Tuusa S, Jokinen M, Linden M, Peltola T, Sol-Gel-Derived TiO2-SiO2 Implant Coatings for Direct Tissue Attachment. Part II: Evaluation of Cell Response (accepted, Journal of Materials Science: Materials in Medicine.

Cacaina, D., Viitala, R., Jokinen, M., Ylänen, H., Hupa, M., Simon, S., In vitro behavior of yttrium silica sol gel microspheres, Bioceramics 17, Key Engineering Materials Vols. 284-286, pp. 411-414

Czyruszkiewicz, T., Ahvenlammi, J., Kortesuo, P., Ahola, M., Kleitz, F., Jokinen, M., Linden, M. and Rosenholm, JB, “Drug release from biodegradable silica fibers” (Journal of Non-Crystalline Solids 306(1) (2002) pp. 1-10.

Jokinen M, Rahiala H, Rosenholm JB. Relation between aggregation and heterogeneity of obtained structure in sol-gel dervice CaO-P2O5-SiO2. J. Sol-Gel Sci. Technol. 12 (1998) 159 – 167.

Jokinen M, Györvary E, Rosenholm JB. Viscoelastic characterization of three different sol-gel derived silica gels. Coll. Surf. A: Physicochem. Eng. Asp. 141 (1998) 205 – 216.

Jokinen M, Pätsi M, Rahiala H, Peltola T, Ritala M, Rosenholm JB. Influence of sol and surface properties on in vitro bioactivity of sol-gel derived TiO2 and TiO2-SiO2 films deposited by dip coating method. J. Biomed. Mater. Res. 42 (1998) 295 – 302.

Jokinen M, Peltola T, Veittola S, Rahiala H, Rosenholm JB. Adjustable biodegradation for ceramic fibres from silica sols. J. Eur. Cer. Soc. 20 (2000) 1739 – 1748.

Jokinen M, Peltola T, Veittola S, Simola J, and Yli-Urpo A, “Colloidal Dimensions versus Biodegradation and Calcium Phosphate Formation on Sol-Gel Derived Silica Fibers” (Bioceramics 14, Key Engineering Materials Vols. 218-220 (2002) pp. 283-286).

Koskinen MK, Toriseva M, Ahonen M, Salonen J, Kähäri V-M, Controlled gene delivery using recombinant adenoviruses embedded in silica sol-gel, Eur. Soc. Gene Therapy, Tampere Finland, 4-7.11.2004.

Koskinen, M.K., Säilynoja, E., Ahola, M., Ahonen, M., Kähäri, V-M., Salonen, J.I. Silica solgel as encapsulation material for controlled release of recombinant adenovirus. 5th Ann. Am. Soc. Gene Therapy, Boston, June (2002)

Koskinen, M.K., Toriseva, M., Ahonen, M. Kähäri, V-M., Salonen, J.I. Release of recombinant adenovirus from silica sol-gel. Contr. Rel. Soc. Glasgow, July (2003)

Koskinen, M., Toriseva, M., Jokinen, M., Jalonen, H., Salonen, J., Kähäri, V-M., Properties of Silica Gel in Targeted and Controlled Viral Gene Therapy, American Society of Gene Therapy, 8th Annual Meeting, June 1-5, 2005, St. Louis, Missouri, USA (Molecular Therapy, vol. 11, Suppl. 1 (2005) 1095, S442)

Kortesuo P, Ahola M, Kangas M, Kangasniemi I, Yli-Urpo A, Kiesvaara J. In vitro evaluation of sol-gel processed spray dried silica gel microspheres as carrier in controlled drug delivery. Int. J. Pharm. 200 (2000) 223 – 229.

Kortesuo P, Ahola M, Kangas M, Karlsson S, Kangasniemi I, Yli-Urpo A, Kiesvaara J. Silica xerogel as an implantable carrier for controlled drug delivery – evaluation of drug distribution and tissue effects after implantation. Biomat 21 (2000) 193 – 198.

Kortesuo P, Ahola M, Karlsson S, Kangasniemi I, Kiesvaara J, Yli-Urpo A. Sol-gel processed sintered silica xerogel as a carrier in controlled drug delivery. J. Biomed. Mater. Res. 44 (2000) 162 – 167.

Kortesuo P, Ahola M, Kangas M, Jokinen M, Leino T, Vuorilehto L, Laakso S, Kiesvaara J, Yli-Urpo A, Marvola M. Effect of synthesis parameters of the sol-gel- processed spray dried silica gel microparticles on the release rate of dexmedetomidine hydrochloride. Biomat. 23(2002) 2795-2801.

Kortesuo P, Ahola M, Kangas M, Leino T, Laakso S, Vuorilehto L, Yli-Urpo A, Kiesvaara J, Marvola M. Alkyl-substituted silica xerogels as carrier in controlled release of dexmedetomidine HCl. J. Contr. Rel. 76(2001) 227-238.

Kortesuo P, Ahola M, Kangas M, Yli-Urpo A, Kiesvaara J, Marvola M. In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel formulation parameters. Int. J. Pharm. 212 (2001) 121-130.

Korventausta, J., Jokinen, M., Rosling, A., Peltola, T. and Yli-Urpo, A., Calcium Phosphate Formation and Ion Dissolution Rates in Silica Gel-PDLLA composites (Biomaterials, 24 (2003 5173-5182).

Korventausta J, Rosling A, Andersson J, Lind A, Linden M, Jokinen M, Yli-Urpo A, Bioactive glass (S53P4) and mesoporous MCM-41-type SiO2 adjusting In vitro bioactivity of porous PDLLA, Bioceramics 16, Key Engineering Materials Vols. 254-256(2004) pp. 557-560.

Peltola T, Jokinen M, Rahiala H, Levänen E, Rosenholm JB, Kangasniemi I, Yli-Urpo A. Calcium phosphate formation on porous sol-gel-derived SiO2 and CaO-P2O5-SiO2 substrates in vitro. J. Biomed. Mat. Res. 44 (1999) 12 – 21.

Peltola T, Jokinen M, Rahiala H, Pätsi M, Heikkilä J, Kangasniemi I, Yli-Urpo A. Effect of aging time of sol on structure and in vitro calcium phosphate formation of sol-gel derived titania films. J. Biomed. Mat. Res. 51 (2000) 200-208 .

Peltola T, Jokinen M, Veittola S, Rahiala H and Yli-Urpo A, Influence of sol and stage of spinnability on in vitro bioactivity and solubility of sol-gel-derived SiO2 fibers (Biomaterials, 22/6 (2001) pp. 589-598).

Peltola T, Jokinen M, Veittola S, Simola J and Yli-Urpo A, In vitro bioactivity and structural features of mildly heat-treated sol-gel-derived silica fibers J. Biomed. Mat. Res. 54 (2001) 579-590).

Peltola T, Ääritalo V, Haltia AM, Vehviläinen M, Areva S, Jokinen M, and Yli-Urpo A, In Vitro Bioactivity of Sol-Gel-Derived Silica Fiber AND P(L/D,L)LA Composite (Bioceramics 15, Key Engineering Materials, Vols. 240-242 (2003) pp. 159-162

Vaahtio M, Jokinen M, Rosling A, Kortesuo P, Kiesvaara J and Yli-Urpo A, Drug release from poly(D,L- lactide)/SiO2 composites, Bioceramics 16, Key Engineering Materials, Vols. 254-256(2004) pp. 489-492.

Viitala RI, Langlet M, Simola J, Lindén M, Rosenholm JB. Aerosol-gel deposition of doped titania thin films. Thin Solid Films 368 (2000) 35-40.

Viitala R, Simola J, Peltola T, Rahiala H, Lindén M, Langlet M, Rosenholm JB. In vitro delivery of aerosol-gel TiO2 thin coatings. J. Biomed. Mat. Res. 54 (2001) 109-114.

Viitala R, Jokinen M, Peltola T, Gunnelius K and Rosenholm JB. Surface Properties of In Vitro Bioactive and Non-Bioactive Sol-Gel Derived Materials. Biomaterials 23(2002) 3073-86.

Viitala R, Jokinen M, Tuusa S, Rosenholm JB and Jalonen H, Adjustably Biodegradable Sol-Gel Derived SiO2 Matrices for Protein Release (Journal of Sol-Gel Science and Technology 36 (2005) p. 147-156).

Viitala R, Jokinen M, Maunu S-L, Jalonen H, Rosenholm JB, Chemical Characterisation of Bioresorbable Sol-Gel Derived SiO2 Matrices Prepared at Protein-Compatible pH (Journal of Non-Crystalline Solids 351 (2005) p. 3225-3234).

Viitala R, Jokinen M, Rosenholm JB, Mechanistic Studies on Release of Large and Small Molecules From Biodegradable SiO2 (In Press, International Journal of Pharmaceutics).

Wilson T, Viitala R, Jalonen H, Penttinen R, Jokinen M, The Release and Biological Activity of Lysozyme from Selected Sol-gel Derived SiO2 Matrices (submitted to Journal of Materials Science: Materials in Medicine).

Väkiparta M, Jokinen M, Vaahtio M, Vallittu P, Yli-Urpo A, The degradation and bioactivity of composites of silica xerogel and novel biopolymer of hydroxyproline, Bioceramics 16, Key Engineering Materials, Vols. 254-256(2004) pp. 553-556.

Ääritalo V, Areva S, Jokinen M, Linden M, Peltola T, , Sol-Gel-Derived TiO2-SiO2 Implant Coatings for Direct Tissue Attachment. Part I: Design, Preparation and Characterization (accepted, Journal of Materials Science: Materials in Medicine).

PhD theses:

Ahola, M., Sol-Gel Derived silica Gels in Controlled Drug Delivery: Evaluation of Tissue Effects and Possibilities to Control the Release Rate of Drug. University of Turku (2001).

Jokinen, M., Bioceramics by Sol-Gel Method: Processing and Properties of Monoliths, Films and Fibres. Åbo Akademi University (1999).

Kortesuo, P., Sol-Gel Derived Silica Gel Monoliths and Microparticles as Carrier in Controlled Drug Delivery in Tissue Administration. University of Helsinki (2001).

Peltola T., Nanoscale Dimensions And In Vitro Calcium Phosphate Formation: Studies on Sol-Gel-Derived Materials and Bioactive Glass, PhD Thesis, University of Turku (2000).

Viitala, R., Characterisation of films, monoliths and microparticles prepared with sol-gel method and studies on in vitro bioactivity and controlled drug release, PhD Thesis, Åbo Akademi University (2005).

The abstracts of many of these listed papers can be found at: http://www.ncbi.nlm.nih.gov/PubMed/ or at http://www.scirus.com/