Technology

Selected publications

The silica-based drug delivery technology and its scientific basis has been validated in numerous scientific studies since early 90's.

A selection of publications related to DelSiTechTMSilica Matrix. The abstracts of many of the listed papers can be found here

Ahola M, Kortesuo P, Kangasniemi I, KiesvaaraJ, Yli-Urpo A. In vitro release behaviour of toremifene citrate from sol-gel processed sintered solica xerogels. Drug Dev. & Ind. Pharm. 25 (1999) (8)955 – 959.

Jokinen M, Peltola T,Veittola S, Rahiala H, Rosenholm JB. Adjustable biodegradation for ceramic fibres from silica sols. J. Eur. Cer. Soc. 20 (2000)1739 – 1748. 

Kortesuo P, Ahola M, Kangas M, Kangasniemi I,Yli-Urpo A, Kiesvaara J. In vitro evaluation of sol-gel processed spray driedsilica gel microspheres as carrier in controlled drug delivery. Int. J. Pharm.200 (2000) 223 – 229.

Kortesuo P, Ahola M, Kangas M, Karlsson S,Kangasniemi I, Yli-Urpo A, Kiesvaara J. Silica xerogel as an implantable carrier for controlled drug delivery – evaluation of drug distribution and tissue effects after implantation. Biomaterials 21 (2000) 193 – 198. 

Kortesuo P, Ahola M, Kangas M, Yli-Urpo A,Kiesvaara J, Marvola M. In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel formulation parameters. Int. J. Pharm. 212 (2001)121-130. 

Kortesuo P, Ahola M, Kangas M, Jokinen M, LeinoT, Vuorilehto L, Laakso S, Kiesvaara J, Yli-Urpo A, Marvola M. Effect of synthesis parameters of the sol-gel- processed spray dried silica gel microparticles on the release rate of dexmedetomidine hydrochloride. Biomaterials23(2002) 2795-2801. 

Viitala R, Jokinen M, Tuusa S, Rosenholm JB andJalonen H, Adjustably biodegradable sol-gel derived SiO2 matrices for protein release. J. Sol-Gel Sci. Tech. 36 (2005) p. 147-156.

Viitala R, Jokinen M, Maunu S-L, Jalonen H,Rosenholm JB, Chemical characterisation of bioresorbable sol-gel derived SiO2 matrices prepared at protein-compatible pH. J. Non-Crystalline Sol. 351 (2005) p.3225-3234. 

Viitala R, Jokinen M, Rosenholm JB. Mechanistic studies on release of large and small molecules from biodegradable SiO2.Int. J. Pharm. 336 (2007) p. 382-390. 

Jokinen M, Koskinen M, Areva S, Rationale of using conventional sol-gel derived SiO2 for delivery of biologically active agents. Progress in Bioceramics: Key Engineering Materials 377, (2008),195-210. 

Kangasniemi L, Koskinen M, Jokinen M, Ala-Aho R, Kähäri V-M, Toriseva M, Jalonen H, Ylä-Herttuala S, Moilanen H, Stenman U-H, Kanerva A, Pesonen S, Hakkarainen T, and Hemminki A, Extended release of adenovirus from silica implants in vitro and in vivo, Gene Therapy 16(1).(2009), pp. 103 – 110. 

Kangasniemi L, ParviainenS, Pisto T, Koskinen M, Jokinen M, Kiviluoto T, Cerullo V, Jalonen H, Koski A, Kangasniemi A, Kanerva A, Pesonen S, Hemmink A, Effects of capsid-modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer, International Journal of Cancer, Volume 131 (1), 2012, pp.253–263.

NEW! Koskimäki J, Tarkia M, Ahtola-Sätilä T, Saloranta L, Simola O, Forsback AP, Frantzen J. Intracranial biodegradable silica-based nimodipine drug release implant for treating vasospasm in subarachnoid hemorrhage in an experimental healthy pig and dog model. BioMed Research International, 2015, Article ID 715752, 10 pages